Lowe will appear in the season-four premiere of Showtime's "Californication," playing movie star Eddie Nero. Lowe's character is being considered for a role playing David Duchovny's Hank Moody in the film version of a book by Moody.
According to Showtime, Lowe is locked in for one episode but might recur.
Lowe was nominated for an Emmy and two Golden Globes for his work on "The West Wing." His last appearance on "B&S" will be in the May 16 season finale.
Correction: Lowe will appear in the fourth season, but not the season premiere.